Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Migraine and cardiovascular disease: systematic review and meta-analysis
This systematic review and meta-analysis evaluated the link between migraine and cardiovascular disease. Researchers examined stroke, myocardial infarction, and cardiovascular-related death. They included…
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EFNS guideline on the drug treatment of migraine – revised report of an EFNS task force
Migraine significantly affects many people, causing major disruption to their lives. This guideline aims to provide evidence-based recommendations for treating various migraine syndromes. A thorough literature search…
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Global prevalence of chronic migraine: A systematic review
This review aimed to summarize studies on chronic migraine (CM) prevalence. Researchers conducted a systematic search for relevant population-based studies. Sixteen publications were accepted, representing twelve…
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Origin of pain in migraine: evidence for peripheral sensitisation
Migraine is the most common neurological disorder affecting millions worldwide. Recent research has shed light on its complex mechanisms. The origin of pain in the trigeminal nerve remains uncertain, despite…
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Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study
This study explores how acute migraine medications affect the transition from episodic migraine (EM) to chronic migraine (TM). Researchers followed 8219 EM patients over five years. They found that 2.5% developed TM…
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Migraine Intervention With STARFlex Technology (MIST) Trial
Migraine with aura often correlates with the presence of patent foramen ovale, or PFO. Closure of PFO has shown promising results in observational studies, with 80% of patients improving. This study aimed to evaluate…
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Cutaneous allodynia in the migraine population
This study focused on assessing cutaneous allodynia (CA) in migraine patients. Researchers developed a questionnaire called the Allodynia Symptom Checklist. This checklist helped evaluate CA symptoms among 11,388…
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Topiramate Reduces Headache Days in Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Study
This study investigated the effectiveness of topiramate for chronic migraine prevention. Chronic migraine affects many individuals and causes significant disability. Preventive treatments are crucial, but data on…
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The Triggers or Precipitants of the Acute Migraine Attack
This study aimed to identify triggers for acute migraine attacks. Patients rated their triggers on a scale from zero to three. The research included 1,207 patients diagnosed with migraines. About 76% of participants…
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Migraine prevalence, disease burden, and the need for preventive therapy
Migraine is a common issue affecting many people in the United States. This study aimed to reassess migraine prevalence and treatment patterns among the population. Researchers mailed a validated headache…
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Migraine and Risk of Cardiovascular Disease in Women
Migraine with aura is linked to a higher cardiovascular risk profile in women. This study involved 27,840 US women aged 45 years or older. All participants were free of cardiovascular disease and angina at the start…
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New Appendix Criteria Open for a Broader Concept of Chronic Migraine
Chronic migraine (CM) and medication overuse headache (MOH) diagnoses have changed recently. Very few patients fit the previous diagnostic criteria for CM. The old system required discontinuation of medication…
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Suppression of cortical spreading depression in migraine prophylaxis
Topiramate, valproate, propranolol, amitriptyline, and methysergide are commonly used for migraine prevention. However, their exact action mechanisms remain uncertain. Cortical spreading depression (CSD) is linked to…
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Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
Familial hemiplegic migraine is a severe type of migraine with aura. It often includes some level of hemiparesis during migraine attacks. Researchers previously identified mutations in two genes linked to this…
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Acupuncture for Patients With Migraine
Acupuncture is commonly used to prevent migraine attacks, but evidence is limited. This study examines acupuncture's effectiveness compared to sham acupuncture and no acupuncture. The trial involved 302 patients…
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Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies
This research examines the link between migraine and ischaemic stroke risk. It includes a systematic review and meta-analysis of studies from 1966 to 2004. Fourteen studies were analyzed, consisting of 11…
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Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine
Calcitonin gene-related peptide (CGRP) is linked to migraine attacks. Researchers tested a CGRP-receptor antagonist, BIBN 4096 BS, for treating migraines. This trial involved 126 patients who received either placebo…
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A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression
Migraine is a common and disabling neurovascular disorder with unknown causes. One subtype is familial hemiplegic migraine type 1, caused by mutations in the CACNA1A gene. This gene encodes a key subunit of calcium…
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Topiramate for Migraine Prevention<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Topiramate is an antiepileptic drug that may help prevent migraines. A large study tested topiramate's efficacy and safety in preventing migraines. The study included 483 patients aged 12 to 65 years. These patients…
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Migraine as a Risk Factor for Subclinical Brain Lesions
Migraine patients may have a higher prevalence of brain lesions. This study evaluated Dutch adults aged 30 to 60 years. Researchers compared migraine patients with controls for brain infarcts and white matter…