Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 / TRPV1 / MAPK signaling axis.
Chronic migraine (CM) is a common neuroinflammatory disorder with few treatment options. Xiongzhi Qufeng Zhitong Granules (XZQF) are a traditional Chinese medicine showing anti-migraine potential. This study explored…
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Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.
This study examined weight loss with atogepant 60 mg daily for migraine treatment. Participants had chronic or episodic migraine and had previously failed several medications. Obesity increases migraine risk…
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CGRP-Targeted Therapy in Vestibular Migraine-How Strong Is the Evidence?
CGRP-targeted therapies have shown promise in reducing migraine symptoms for many patients. However, evidence for their effectiveness in vestibular migraine is limited and preliminary. Current literature on…
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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review).
Migraines are common and debilitating neurological disorders affecting many people. Central sensitisation is the main cause of their recurrent and chronic nature. Transient receptor potential vanilloid 1, or TRPV1…
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Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine.
This study examined the effects of botulinum toxin type A on chronic migraine. Forty women with chronic migraine received varying lengths of BoNTA treatment. Researchers evaluated migraine frequency, pain burden, and…
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Efficacy, tolerability and barriers to the use of anti-CGRP medications among migraine patients in Egypt: real world experience.
This study evaluated the real-world use of anti-CGRP therapies in Egypt. Researchers focused on effectiveness, tolerability, barriers to access, and treatment adherence. Eighty migraine patients participated…
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Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine.
Migraine is a chronic neurological disorder causing recurrent, pulsating headaches. It often comes with symptoms like visual aura, phonophobia, and gastrointestinal issues. Natural bioactive products from traditional…
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Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.
Rosacea is a chronic skin condition linked to ocular symptoms and migraines. This study compared inflammatory and hematological markers in rosacea patients and healthy controls. A total of 150 rosacea patients…
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Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.
In a study comparing treatments for migraine, researchers evaluated calcitonin gene-related peptide monoclonal antibodies, or CGRP mAbs, and onabotulinumtoxinA. They aimed to determine if CGRP mAbs were non-inferior…
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Efficacy Evaluation of Right-Heart Contrast Echocardiography Combined With the Valsalva Manoeuvre in Screening for Patent Foramen Ovale in Patients With Migraine Without an Identified Secondary Cause.
This study evaluated the effectiveness of right-heart contrast echocardiography (RHCE) with the Valsalva manoeuvre. It focused on screening for patent foramen ovale (PFO) in migraine patients. A total of 232 patients…
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Misophonia, Autistic Traits, and Obsessive-Compulsive Symptoms in Migraine: A Controlled Comparative Study.
This study looked at misophonia in adolescents with migraine compared to controls. It involved 80 participants aged 15-18 years, half with migraine. Researchers used various scales to assess misophonia…
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To dig oneself into a hole or to dig the tunnel to the core? A study on the Swartz sheath support strategy for patent foramen ovale closure in migraine patients.
Closing a patent foramen ovale (PFO) can help migraine patients. However, small shunt PFOs present challenges for multipurpose angiographic catheters. This study introduces a new procedural approach using the Swartz…
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Concurrent VVOR and VORS profiling reveals a threshold-dependent VOR suppression deficit in vestibular migraine.
This study examined visual-vestibular integration in vestibular migraine patients. Researchers compared 57 patients with vestibular migraine to 30 healthy controls. They assessed visually enhanced vestibulo-ocular…
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[Pharmacological characteristics and clinical outcomes of Rimegepant (Nurtec<sup>®</sup> ODT), an oral CGRP receptor antagonist for the acute treatment and prevention of migraine].
Migraine is a common neurological disorder that causes significant burden on individuals. Current treatments face challenges like contraindications and delayed effectiveness. Rimegepant is a new oral medication…
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Short-Term Changes in Migraine Burden After Roux-en-Y Gastric Bypass: A Prospective Cohort Study.
Obesity is linked to more frequent and severe migraines. Roux-en-Y gastric bypass may help reduce migraine burden. This study involved 52 adults with severe obesity and established migraines. Participants underwent…
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Hypothalamus as a conductor of the migraine prodrome: A narrative review.
This narrative review discusses the hypothalamus's role in migraine prodrome. Prodrome is the initial phase of a migraine attack. Understanding this phase can help explain migraine initiation. It may also identify…