Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
The study explored erenumab's safety and efficacy in chronic migraine patients. Researchers conducted a phase 2, randomized, double-blind trial across 69 centers in North America and Europe. Participants were adults…
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The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
Calcitonin gene-related peptide, or CGRP, is a vital 37-amino acid peptide. It is mainly found in sensory fibers from the dorsal root and trigeminal ganglia. CGRP also exists in the central nervous system. This…
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Pathophysiology of Migraine: A Disorder of Sensory Processing
Migraine affects over one billion people globally and is highly disabling. Its pathophysiology has evolved significantly from ancient theories to modern neurological understanding. Researchers consider three main…
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Sex differences in the epidemiology, clinical features, and pathophysiology of migraine
Migraine affects women two to three times more than men. Women experience longer attacks and increased headache recurrence. They also report greater disability and longer recovery times. Comorbidities, such as…
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Chronic migraine: risk factors, mechanisms and treatment
Chronic migraine significantly impacts patients' lives, affecting their quality and socioeconomic functioning. It affects 1-2% of the general population and 8% of migraine patients. Chronic migraine usually develops…
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Migraine affects about 14% of people globally and is quite debilitating. Its underlying causes remain unclear, sparking debate about vascular versus neuronal dysfunction. Previous studies found 13 loci linked to…
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The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks
Recent research explored brain activity during migraines using advanced imaging techniques. Specifically, positron emission tomography and functional magnetic resonance imaging were utilized. The study identified a…
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Migraine: Multiple Processes, Complex Pathophysiology
Migraine is a common, hereditary neurovascular headache disorder affecting many individuals. It often begins in childhood, increasing from a few times yearly to weekly in adulthood, especially in females. Migraine…
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The Acute Treatment of Migraine in Adults: The <scp>A</scp> merican <scp>H</scp> eadache <scp>S</scp> ociety Evidence Assessment of Migraine Pharmacotherapies
This study reviews evidence for medications used to treat acute migraine attacks. It updates previous guidelines from the American Academy of Neurology published in 2000. A comprehensive literature search identified…
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Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases
Certain headaches arise from intracranial pathologies, like meningitis or tumors. These headaches result from mechanical or chemical stimulation of sensitive structures. Migraines, however, have an unknown origin and…
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Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
Migraine involves inherited changes in brain excitability and pain pathways. The trigeminovascular pathway plays a key role in migraine development. Intracranial arterial dilation contributes to migraine symptoms as…
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Pathophysiology of Migraine
Migraine is a complex neurological condition involving the brain and its tissues. Initially thought to be a blood vessel disorder, new evidence suggests otherwise. Migraine results from interactions within the…
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Vestibular migraine: Diagnostic criteria
This paper outlines the diagnostic criteria for vestibular migraine. These criteria were developed by the Bárány Society and the International Headache Society. The classification includes vestibular migraine and…
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Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults
This research provides updated recommendations for preventing migraine headaches. The authors aimed to identify effective pharmacologic therapies for migraine prevention. They analyzed studies published from June…
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Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury
Cortical spreading depression (CSD) is linked to brain ion homeostasis failure. It leads to the release of excitatory amino acids from nerve cells. CSD is associated with increased energy metabolism and changes in…
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Prevalence of headache and migraine in children and adolescents: a systematic review of population‐based studies
This study reviews the prevalence of headache and migraine in children and adolescents. Researchers analyzed 50 population-based studies conducted from 1990 to 2007. The estimated prevalence of headache in this group…
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Disability, HRQoL and resource use among chronic and episodic migraineurs: Results from the International Burden of Migraine Study (IBMS)
Migraine significantly impacts patients, families, and health care systems worldwide. This study compared chronic migraine (CM) and episodic migraine (EM) sufferers' experiences. Researchers wanted to see if migraine…
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OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial
This study investigates the effectiveness of onabotulinumtoxinA for chronic migraine treatment. It is part of the PREEMPT 1 trial, focused on safety and efficacy. The study lasted 24 weeks and included a…
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OnabotulinumtoxinA for Treatment of Chronic Migraine: Pooled Results From the Double‐Blind, Randomized, Placebo‐Controlled Phases of the PREEMPT Clinical Program
This research investigates onabotulinumtoxinA, commonly known as BOTOX, for chronic migraine treatment. Chronic migraine is a common, debilitating condition that often remains untreated. The study pooled results from…
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Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers
This research aimed to compare the sociodemographic profiles of chronic migraine and episodic migraine sufferers. The study analyzed data from the AMPP survey, which included 24,000 headache sufferers. Among them…