Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Safety and tolerability of transnasal evaporative cooling for the acute treatment of migraine in an at-home setting: A randomized, double-blind, sham-controlled, decentralized clinical trial.
Transnasal evaporative cooling (TNEC) may help manage migraine symptoms. This study assessed TNEC's safety and tolerability in adults with migraine. It took place in the U.S. from November 2023 to June 2024…
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IL-17A, IL-17RA, and IL-22 as biomarkers in migraine: associations with disease activity and clinical features.
Migraine is increasingly seen as a neuroinflammatory disorder linked to immune processes. This study examined levels of Th17-related cytokines, specifically IL-17A, IL-17RA, and IL-22. Researchers included 99…
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Early and clinically meaningful functional improvement following CGRP monoclonal antibodies in adolescents with migraine: A real-world retrospective study.
CGRP monoclonal antibodies (mAb) could help adolescents with migraines. This study focused on adolescents aged 15-17 years who received CGRP mAb therapy for migraine. It evaluated early functional outcomes in daily…
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The special extract ERr 731<sup>®</sup> from the root of rhapontic rhubarb (<i>Rheum rhaponticum</i>): efficacy in headache/migraine and further climacteric complaints in women in the perimenopause.
Menopause triggers neuroendocrine changes and various climacteric symptoms in women. Hormone replacement therapy (HRT) is the standard treatment but has safety concerns. This study explored ERr 731®, a non-hormonal…
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Combined biofeedback and vestibular rehabilitation therapy for vestibular migraine: clinical efficacy and neurobiochemical correlates.
Vestibular migraine (VM) leads to recurrent vertigo with limited treatment options available. This study explored the combined effects of biofeedback therapy and vestibular rehabilitation. Researchers enrolled 148 VM…
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Investigating the Patent Foramen Ovale-Migraine Link in Southern Saudi Arabia.
Migraine is a disabling neurological condition linked to patent foramen ovale (PFO). This study involved 45 patients from January to April 2024. There were 30 migraine patients with PFO and 15 without PFO. All…
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Migraine and risk of adverse obstetric outcomes: a matched cohort study of English linked electronic health records.
This study explored how pre-pregnancy migraine affects obstetric outcomes in women. Researchers analyzed linked electronic health records from England, focusing on women aged 15-50 years. They evaluated 428,217…
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Peptidomics profiling identifies endogenous peptides associated with meningeal afferent activation in a chronic migraine mouse model.
Migraine is a disabling disorder that affects many people worldwide. It significantly impacts quality of life due to its debilitating symptoms. Recent studies suggest that endogenous peptides play vital roles in…
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Iatrogenic harm in paediatric and adolescent populations of patients with migraine: A systematic review with meta-analysis.
Migraine significantly impacts children and adolescents, causing a high disability burden. The effectiveness of pharmacological treatments remains debated, raising safety concerns among young patients. This study…
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Efficacy of prefrontal-occipital transcranial direct current stimulation for refractory chronic migraine.
Patients with chronic migraine often do not respond to standard medical treatments. This resistance likely comes from the complex nature of their pain. Transcranial direct current stimulation, or tDCS, is a new…
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Three-Year Interim Results from a Post-Marketing Surveillance Study of Patients with Migraine Treated with Fremanezumab in South Korea.
Fremanezumab is being evaluated for its safety and effectiveness in South Korea. This study focuses on adults with migraines using fremanezumab for the first time. It is a 6-year, non-interventional study across 60…
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Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).
Rimegepant is a CGRP receptor antagonist for treating episodic migraines. This study examined rimegepant's effectiveness in patients with previous treatment failures. It was conducted across nine headache units in…
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The association between social risk profile and self-reported severe headache or migraine with all-cause mortality risk: A machine learning-based prediction model and interpretability analysis.
This study investigates how social risk factors affect migraines and mortality. Researchers used data from 11,861 US adults collected between 1999 and 2004. They examined the relationship between social risk profile…
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Thiamine deficiency in patients with chronic migraine: A case-control study.
Thiamine deficiency is noted in various neurological disorders, including chronic migraine (CM). This study aimed to compare serum thiamine levels in CM patients and healthy controls. A total of 100 adults with CM…
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Potential role of tirzepatide, a dual GLP-1 and GIP receptor agonist, for preventive treatment of migraine: A case series.
Obesity often worsens migraine symptoms and increases their frequency and severity. Recent studies indicate that GLP-1 receptor agonists may help in pain modulation. Researchers observed two patients with migraine…
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Adverse childhood experiences, migraine, and adverse pregnancy outcomes among teenage mothers.
This study explored how adverse childhood experiences (ACEs) and migraine relate to pregnancy outcomes. Teenage mothers face higher risks for adverse birth outcomes than adults. The research included 819 Peruvian…
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Effect of chronic migraine treatment on functional seizure frequency: An exploratory study.
Chronic migraine often coexists with functional seizures, which are challenging to manage. This study aimed to see if migraine treatment impacts seizure frequency in patients. Researchers selected patients suffering…
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Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine.
Understanding age-related changes in migraine is crucial as life expectancy increases. Both aging and migraine are significant cardiovascular risk factors. Researchers studied how calcitonin gene-related peptide…
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Cerebrovascular reactivity in migraine: a breath-hold BOLD fMRI study.
This study focused on cerebrovascular reactivity (CVR) in migraine patients. Previous studies used Doppler ultrasonography, limiting their findings to large vascular areas. New functional MRI techniques offer higher…
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Profile of migraine patients in Middle East and North Africa (MENA) region: a multi-center study.
The Middle East and North Africa (MENA) region faces unique migraine challenges. This study examined differences between migraine patients in low-/lower-middle-income and high-/upper-middle-income countries. It…