Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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The Triggers or Precipitants of the Acute Migraine Attack
This study aimed to identify triggers for acute migraine attacks. Patients rated their triggers on a scale from zero to three. The research included 1,207 patients diagnosed with migraines. About 76% of participants…
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Migraine prevalence, disease burden, and the need for preventive therapy
Migraine is a common issue affecting many people in the United States. This study aimed to reassess migraine prevalence and treatment patterns among the population. Researchers mailed a validated headache…
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Migraine and Risk of Cardiovascular Disease in Women
Migraine with aura is linked to a higher cardiovascular risk profile in women. This study involved 27,840 US women aged 45 years or older. All participants were free of cardiovascular disease and angina at the start…
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New Appendix Criteria Open for a Broader Concept of Chronic Migraine
Chronic migraine (CM) and medication overuse headache (MOH) diagnoses have changed recently. Very few patients fit the previous diagnostic criteria for CM. The old system required discontinuation of medication…
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Suppression of cortical spreading depression in migraine prophylaxis
Topiramate, valproate, propranolol, amitriptyline, and methysergide are commonly used for migraine prevention. However, their exact action mechanisms remain uncertain. Cortical spreading depression (CSD) is linked to…
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Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
Familial hemiplegic migraine is a severe type of migraine with aura. It often includes some level of hemiparesis during migraine attacks. Researchers previously identified mutations in two genes linked to this…
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Acupuncture for Patients With Migraine
Acupuncture is commonly used to prevent migraine attacks, but evidence is limited. This study examines acupuncture's effectiveness compared to sham acupuncture and no acupuncture. The trial involved 302 patients…
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Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies
This research examines the link between migraine and ischaemic stroke risk. It includes a systematic review and meta-analysis of studies from 1966 to 2004. Fourteen studies were analyzed, consisting of 11…
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Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine
Calcitonin gene-related peptide (CGRP) is linked to migraine attacks. Researchers tested a CGRP-receptor antagonist, BIBN 4096 BS, for treating migraines. This trial involved 126 patients who received either placebo…
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A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression
Migraine is a common and disabling neurovascular disorder with unknown causes. One subtype is familial hemiplegic migraine type 1, caused by mutations in the CACNA1A gene. This gene encodes a key subunit of calcium…
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Topiramate for Migraine Prevention<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Topiramate is an antiepileptic drug that may help prevent migraines. A large study tested topiramate's efficacy and safety in preventing migraines. The study included 483 patients aged 12 to 65 years. These patients…
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Migraine as a Risk Factor for Subclinical Brain Lesions
Migraine patients may have a higher prevalence of brain lesions. This study evaluated Dutch adults aged 30 to 60 years. Researchers compared migraine patients with controls for brain infarcts and white matter…
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Defeating migraine pain with triptans: A race against the development of cutaneous allodynia
Many migraine patients find triptan therapy helpful for pain relief. However, some do not experience relief. This study investigates how cutaneous allodynia affects triptan therapy success. Cutaneous allodynia…
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A self-administered screener for migraine in primary care
Migraine is a common and disabling condition often undiagnosed in primary care. This study developed a self-administered migraine screener for patients with headache complaints. A total of 563 patients completed this…
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Comorbidity of migraine and depression
Researchers found a strong link between migraine and major depression in this study. They examined adults aged 25 to 55 years with migraines, other headaches, and no severe headaches. Participants were interviewed in…
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Premonitory symptoms in migraine
Migraine commonly includes nonheadache symptoms before, during, and after attacks. However, premonitory symptoms before the headache have not been extensively studied. If these symptoms accurately forecast migraines…
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Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2
Migraine is a common and disabling disorder affecting 12% of the population. Many people with migraine, about 20%, experience aura before or during headaches. Genetic factors play a significant role, especially in…
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Triptans (Serotonin, 5-HT<sub>1B/1D</sub> Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials
Triptans are effective acute migraine medications that act on serotonin receptors. Seven different triptans will soon be available in 13 oral doses. This creates a need for evidence-based selection guidelines for…
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Cgrp May Play A Causative Role in Migraine
Calcitonin gene-related peptide, or CGRP, is linked to migraine attacks. This study investigated if CGRP causes headaches or is a result of migraines. Twelve patients with migraine without aura participated in a…
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Migraine in the United States
A study examined migraine prevalence and healthcare use in the United States. Researchers conducted a telephone interview survey in Philadelphia County, Pennsylvania, in 1998. The survey identified individuals with…