Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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The Acute Treatment of Migraine in Adults: The <scp>A</scp> merican <scp>H</scp> eadache <scp>S</scp> ociety Evidence Assessment of Migraine Pharmacotherapies
This study reviews evidence for medications used to treat acute migraine attacks. It updates previous guidelines from the American Academy of Neurology published in 2000. A comprehensive literature search identified…
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Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases
Certain headaches arise from intracranial pathologies, like meningitis or tumors. These headaches result from mechanical or chemical stimulation of sensitive structures. Migraines, however, have an unknown origin and…
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Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
Migraine involves inherited changes in brain excitability and pain pathways. The trigeminovascular pathway plays a key role in migraine development. Intracranial arterial dilation contributes to migraine symptoms as…
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Pathophysiology of Migraine
Migraine is a complex neurological condition involving the brain and its tissues. Initially thought to be a blood vessel disorder, new evidence suggests otherwise. Migraine results from interactions within the…
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Vestibular migraine: Diagnostic criteria
This paper outlines the diagnostic criteria for vestibular migraine. These criteria were developed by the Bárány Society and the International Headache Society. The classification includes vestibular migraine and…
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Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults
This research provides updated recommendations for preventing migraine headaches. The authors aimed to identify effective pharmacologic therapies for migraine prevention. They analyzed studies published from June…
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Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury
Cortical spreading depression (CSD) is linked to brain ion homeostasis failure. It leads to the release of excitatory amino acids from nerve cells. CSD is associated with increased energy metabolism and changes in…
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Prevalence of headache and migraine in children and adolescents: a systematic review of population‐based studies
This study reviews the prevalence of headache and migraine in children and adolescents. Researchers analyzed 50 population-based studies conducted from 1990 to 2007. The estimated prevalence of headache in this group…
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Disability, HRQoL and resource use among chronic and episodic migraineurs: Results from the International Burden of Migraine Study (IBMS)
Migraine significantly impacts patients, families, and health care systems worldwide. This study compared chronic migraine (CM) and episodic migraine (EM) sufferers' experiences. Researchers wanted to see if migraine…
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OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial
This study investigates the effectiveness of onabotulinumtoxinA for chronic migraine treatment. It is part of the PREEMPT 1 trial, focused on safety and efficacy. The study lasted 24 weeks and included a…
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OnabotulinumtoxinA for Treatment of Chronic Migraine: Pooled Results From the Double‐Blind, Randomized, Placebo‐Controlled Phases of the PREEMPT Clinical Program
This research investigates onabotulinumtoxinA, commonly known as BOTOX, for chronic migraine treatment. Chronic migraine is a common, debilitating condition that often remains untreated. The study pooled results from…
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Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers
This research aimed to compare the sociodemographic profiles of chronic migraine and episodic migraine sufferers. The study analyzed data from the AMPP survey, which included 24,000 headache sufferers. Among them…
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Migraine and cardiovascular disease: systematic review and meta-analysis
This systematic review and meta-analysis evaluated the link between migraine and cardiovascular disease. Researchers examined stroke, myocardial infarction, and cardiovascular-related death. They included…
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EFNS guideline on the drug treatment of migraine – revised report of an EFNS task force
Migraine significantly affects many people, causing major disruption to their lives. This guideline aims to provide evidence-based recommendations for treating various migraine syndromes. A thorough literature search…
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Global prevalence of chronic migraine: A systematic review
This review aimed to summarize studies on chronic migraine (CM) prevalence. Researchers conducted a systematic search for relevant population-based studies. Sixteen publications were accepted, representing twelve…
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Origin of pain in migraine: evidence for peripheral sensitisation
Migraine is the most common neurological disorder affecting millions worldwide. Recent research has shed light on its complex mechanisms. The origin of pain in the trigeminal nerve remains uncertain, despite…
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Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study
This study explores how acute migraine medications affect the transition from episodic migraine (EM) to chronic migraine (TM). Researchers followed 8219 EM patients over five years. They found that 2.5% developed TM…
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Migraine Intervention With STARFlex Technology (MIST) Trial
Migraine with aura often correlates with the presence of patent foramen ovale, or PFO. Closure of PFO has shown promising results in observational studies, with 80% of patients improving. This study aimed to evaluate…
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Cutaneous allodynia in the migraine population
This study focused on assessing cutaneous allodynia (CA) in migraine patients. Researchers developed a questionnaire called the Allodynia Symptom Checklist. This checklist helped evaluate CA symptoms among 11,388…
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Topiramate Reduces Headache Days in Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Study
This study investigated the effectiveness of topiramate for chronic migraine prevention. Chronic migraine affects many individuals and causes significant disability. Preventive treatments are crucial, but data on…