Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Safety and Effectiveness of Pain Medications for Migraine Management During Pregnancy and Lactation.
Managing migraines during pregnancy and lactation is quite challenging. There is limited safety data for migraine therapies during these periods. New treatments like CGRP blockers have little safety information…
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The Headache Needs Assessment (HANA) survey: psychometric properties of the Turkish version in migraine.
This study focused on adapting and validating the Turkish version of the Headache Needs Assessment survey. The survey contains seven items that assess migraine needs. Researchers evaluated structural validity using…
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Beyond air pollution: Green space, water minerals, and genetic predisposition in migraine onset.
This research studied the effects of green spaces, coastal distance, and water minerals on migraine onset. The study included 295,881 participants from the UK Biobank. These migraine-free individuals were followed…
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Gender inequities in the economic burden of anxiety disorders, depressive disorders, migraine, and rheumatoid arthritis in Mexico, 2005-2021.
Anxiety disorders, depressive disorders, migraine, and rheumatoid arthritis significantly impact health. These conditions lead to disability, recurrent care needs, and productivity losses. In Mexico, women are…
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Endolymphatic hydrops in patients with migraine: a correlative study.
This study looked at endolymphatic hydrops (EH) in migraine patients. EH is a hallmark of Menière's disease. Researchers examined MRI scans to find correlations with migraine biomarkers. They reviewed 144 inner ear…
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Superior sagittal sinus thrombosis presented as a migraine headache with normal D-dimer: a case report and literature review.
Superior sagittal sinus thrombosis (SSST) is a rare cerebral venous sinus thrombosis. It involves blood clot formation in the superior sagittal sinus. This leads to increased intracranial pressure. A remarkable case…
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Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis.
The glymphatic system is essential for clearing waste from the brain. Dysfunction in this system may contribute to migraine development. The glymphatic system operates similarly to the lymphatic system. It relies on…
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Dual-attention temporal graph neural network on resting-state fMRI dynamic functional connectivity identifies risk-related patterns of migraine chronification.
Migraine chronification is challenging to characterize on an individual basis. There are no robust imaging markers for the conversion from episodic migraine to chronic migraine. This study involved 195 participants…
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Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study.
Headache-associated symptoms like nausea and sensitivity help classify primary headache disorders. We developed a tool called Cluster Analysis of Migraine-Associated Symptoms, or CAMS. This tool captures the…
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EGR1-associated inflammatory and neurovascular signatures suggest a potential link between migraine and ischemic stroke.
Migraine increases the risk of ischemic stroke, but the mechanisms are unclear. This study analyzed RNA-seq data from ischemic stroke and a mouse migraine model. Researchers aimed to identify shared molecular…
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Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling.
Chronic migraine involves neuroinflammation in the trigeminal nucleus caudalis, or TNC. The herbal pair Paeoniae Radix Alba and Chuanxiong Rhizoma is commonly used for treatment. This study examined the effects of…
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Magnitude and Determinants of Placebo Response in Acute Migraine Trials: A Systematic Review and Meta-Analysis.
Migraine is a common and debilitating neurological disorder affecting many people. This study examined the placebo response in acute migraine clinical trials. Researchers analyzed 126 randomized controlled trials…
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Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression.
This study explores the endocannabinoid system's role in migraine and depression. Researchers examined cerebrospinal fluid (CSF) levels of specific endocannabinoids in 194 episodic migraine patients. The participants…
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Real-world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire-5.
The introduction of calcitonin gene-related peptide antagonists has changed migraine treatment. Zavegepant is a third-generation intranasal gepant for acute migraine relief. Although clinical trials show its…
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Development and Validation of a Headache Health Education Program to Serve as a Control Intervention for Non-Pharmacological Studies in Migraine.
As interest grows in non-pharmacologic migraine treatments, a suitable control is vital. Designing effective controls for these treatments presents significant challenges. One solution is developing a credible…
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Beyond migraine: A narrative review of photophobia's clinical spectrum.
Photophobia is a common and often disabling symptom in various conditions. It is particularly prevalent in migraine but also seen in common eye diseases. This review explores the complex interactions between visual…
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An orexinergic circuit driving migraine relief by lavender essential oil.
Lavender essential oil (LEO) may provide relief for chronic migraine sufferers. Current pharmacological treatments often lack long-term effectiveness and suitability. Research shows that LEO inhalation activates…
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Patient Experience with 10 mg Intranasally Administered Zavegepant as an Acute Treatment of Migraine Attacks: Qualitative Research Findings.
Migraine is a significant burden on individuals and healthcare systems alike. This study investigates patient experiences with zavegepant 10 mg intranasal for acute migraine treatment. Adults with self-reported…
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Delayed Access Is a Migraine Risk Factor: Precision Triage as the Missing Link in Modern Headache Care.
Migraine care has advanced in precision, yet many patient pathways remain confusing. Many patients face delays in diagnosis and experience underestimated disability. This leads to increased acute medication use…
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Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials.
This study explored how menopausal hormone therapy affects headache severity in women. Researchers focused on 22,876 postmenopausal women in the Women's Health Initiative trials. They compared the effects of…