Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Impact of Changing Migraine Outcome on Pharmacist Interventions in a Health-System Specialty Pharmacy.
Health-system specialty pharmacies play a crucial role in managing complex medical conditions. They focus on specialized medication therapy management, especially for migraines. This study aimed to evaluate whether…
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Persistent cognitive dysfunction in patients with migraine: a case series.
Cognitive symptoms like impaired concentration, slowed thinking, and forgetfulness are common in migraine patients. While these issues are strongest during attacks and postdrome phases, some individuals face…
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Migraine is associated with altered approach-avoidance decision processing: a case control study.
Individuals with migraine process trigger-related information differently than those without. This study examined decision-making in migraine patients using a virtual T-maze task. Participants faced both visual…
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A delayed endothelial-glial mechanism for CGRP-induced migraine.
CGRP plays a crucial role in migraine and trigeminovascular signaling. However, how CGRP causes delayed migraine-like pain after infusion is unclear. Although evidence supports CGRP’s role, the exact mechanisms…
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Factors Associated with Migraine Attack Duration in Adults: A Cross-Sectional Study.
Migraine is a prevalent neurological disorder with attacks lasting 4-72 hours. This study assessed 694 patients meeting ICHD-3 migraine criteria. Participants were divided into short, medium, and long attack duration…
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Periaqueductal gray matter echogenicity: An irreversible marker of chronic migraine?
This study investigated the periaqueductal gray matter (PAG) in migraine patients. Researchers aimed to see if PAG changes correlate with migraine classification shifts. They reanalyzed data from 115 participants…
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Chronic migraine management with onabotulinumtoxinA and anti-CGRP/R monoclonal antibodies in an Italian real-world setting: update on therapeutic appropriateness and an emerging role of pharmacy.
Migraine is a challenging neurovascular disorder that can progress to chronic forms. This progression may result in medication-overuse headache, leading to higher healthcare costs. The need for preventive treatments…
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Personalized machine learning prediction of next-day migraine persistence using digital headache diary data.
Migraine is a complex neurological disorder with considerable individual differences. Predicting if a migraine will continue into the next day is difficult. This study assessed personalized machine learning models…
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Thyroid dysfunction and migraine across racial and age groups: A multinational cohort study.
This study explores the link between thyroid dysfunction and migraine across different groups. Hypothyroidism affects over 200 million individuals globally, while hyperthyroidism impacts about 3% of adults. Migraine…
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Comparison of greater occipital and supraorbital nerve block with amitriptyline use in migraine treatment.
Migraine is a condition that often requires long-term preventive therapy. This study compares the effectiveness of greater occipital nerve (GON) and supraorbital nerve (SON) blockades against amitriptyline in…
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Regulatory T cell levels in migraine: A systematic review and meta-analysis.
This systematic review and meta-analysis examined regulatory T (Treg) cell levels in migraine patients. Researchers searched databases like PubMed, Embase, and Cochrane for relevant studies. They identified 1,162…
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Selective reduction of thalamic glutathione in migraine in the absence of detectable N-acetylaspartate alterations.
This study explores the role of oxidative stress in migraine. Researchers measured metabolites in the thalamus of 131 participants. These included 36 healthy controls, 46 migraine without aura, 17 migraine with aura…
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Real-world assessment of effectiveness and safety of candesartan in migraine prevention: Results of the French FHU InovPain registry.
Candesartan is recommended for migraine prevention, but real-world data is limited. This study analyzed adults starting candesartan in the French FHU InovPain registry. Patients were assessed at month 3, month 9, and…
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Differentiating Ménière Disease and Vestibular Migraine: A Prospective MRI Study of Endolymphatic Hydrops.
High-resolution MRI has improved the ability to detect endolymphatic hydrops. This advancement helps distinguish Ménière disease (MD) from vestibular migraine (VM). The study focused on patients experiencing vertigo…
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[Transgender health, migraine and headache-Underestimated associations, limited data situation].
Migraine and headache disorders are important in transgender patient care. Gender-affirming hormone therapies cause changes in physiological systems, affecting migraine symptoms. These changes align with the affirmed…
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Targeted liquid chromatography-tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy.
This study explored the role of specific amino acids in chronic migraine patients. Researchers evaluated plasma levels of arginine, histidine, and their derivatives. They aimed to identify potential biomarkers for…
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A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocyte-Platelet Score in Migraine.
Migraine is seen as a neuroinflammatory disorder with various inflammatory responses. This study examined leukocyte-derived indices like the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index…
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Impacts of cervical exercise and Mulligan manual therapy on headache frequency, intensity, and disability for people with episodic migraine - a randomized clinical trial.
This study aimed to compare Mulligan manual therapy (MMT) with sham MMT. Researchers involved 99 adults with episodic migraine, averaging 41.5 years old. Participants received either neck exercises alone, exercises…
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Acute migraine treatments in patients above age 65.
Migraine is common and disabling in older adults. However, research on treatment options for those over 65 years is limited. This age group often faces unique challenges, including special considerations for…
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Headache in mitochondrial diseases: From migraine to stroke-like episodes.
Headaches in primary mitochondrial diseases (PMDs) have unique features needing differentiation. These headaches affect about 55% to 71% of PMD patients. Individuals with mitochondrial encephalomyopathy, lactic…