Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Defeating migraine pain with triptans: A race against the development of cutaneous allodynia
Many migraine patients find triptan therapy helpful for pain relief. However, some do not experience relief. This study investigates how cutaneous allodynia affects triptan therapy success. Cutaneous allodynia…
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A self-administered screener for migraine in primary care
Migraine is a common and disabling condition often undiagnosed in primary care. This study developed a self-administered migraine screener for patients with headache complaints. A total of 563 patients completed this…
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Comorbidity of migraine and depression
Researchers found a strong link between migraine and major depression in this study. They examined adults aged 25 to 55 years with migraines, other headaches, and no severe headaches. Participants were interviewed in…
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Premonitory symptoms in migraine
Migraine commonly includes nonheadache symptoms before, during, and after attacks. However, premonitory symptoms before the headache have not been extensively studied. If these symptoms accurately forecast migraines…
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Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2
Migraine is a common and disabling disorder affecting 12% of the population. Many people with migraine, about 20%, experience aura before or during headaches. Genetic factors play a significant role, especially in…
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Triptans (Serotonin, 5-HT<sub>1B/1D</sub> Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials
Triptans are effective acute migraine medications that act on serotonin receptors. Seven different triptans will soon be available in 13 oral doses. This creates a need for evidence-based selection guidelines for…
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Cgrp May Play A Causative Role in Migraine
Calcitonin gene-related peptide, or CGRP, is linked to migraine attacks. This study investigated if CGRP causes headaches or is a result of migraines. Twelve patients with migraine without aura participated in a…
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Migraine in the United States
A study examined migraine prevalence and healthcare use in the United States. Researchers conducted a telephone interview survey in Philadelphia County, Pennsylvania, in 1998. The survey identified individuals with…
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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
Migraine headaches involve the trigeminal nerve and complex triggering mechanisms. This study links migraine aura to headache development. Researchers demonstrated that cortical spreading depression activates…
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Migraine — Current Understanding and Treatment
This research paper from the New England Journal of Medicine explores migraines. It highlights the latest understanding and treatment options for migraines. Migraines affect millions worldwide, significantly…
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Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials
Oral triptans, serotonin 5-HT(1B/1D) agonists, are effective acute migraine treatments. Seven types of triptans will soon be available, necessitating evidence-based selection guidelines. We analyzed data from 53…
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Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II
This study examined the prevalence and impact of migraine in the United States. Data was collected using a self-administered questionnaire sent to 20,000 households. The response rate was 68.3% among 43,527 eligible…
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Migraine Diagnosis and Treatment: Results From the American Migraine Study II
A population-based survey in 1999 examined migraine diagnosis and medication use. This study involved 3577 individuals experiencing severe headaches, using International Headache Society criteria. Results showed 48%…
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Periaqueductal Gray Matter Dysfunction in Migraine: Cause or the Burden of Illness?
The periaqueductal gray matter (PAG) plays a key role in pain regulation. Researchers studied iron levels in the PAG in patients with episodic migraine (EM) and chronic daily headache (CDH). They used advanced MRI…
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The Clinical Spectrum of Familial Hemiplegic Migraine Associated with Mutations in a Neuronal Calcium Channel
Familial hemiplegic migraine is an autosomal dominant disorder. It features attacks of transient hemiparesis followed by migraine headaches. This condition divides into two categories. Pure familial hemiplegic…
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Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability
The MIDAS Questionnaire was developed to measure headache-related disability in migraine patients. It consists of five questions focused on activity limitations over the past 3 months. Researchers evaluated its…
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Brainstem activation specific to migraine headache
Research indicates that the brainstem activates during migraine without aura (MWOA). In contrast, cluster headaches show hypothalamic activation. This study examined a patient with both migraine and cluster headache…
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Mechanisms of migraine aura revealed by functional MRI in human visual cortex
Cortical spreading depression (CSD) may cause migraine visual aura. Testing this in humans has been difficult. Researchers used high-field functional MRI to study three subjects. They recorded changes in blood…
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Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers
The Migraine Disability Assessment (MIDAS) questionnaire measures headache-related disability over three months. It has moderately high test-retest reliability among headache sufferers. This study aimed to assess the…
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The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine
Most migraine patients experience cutaneous allodynia during their attacks. This study analyzed how cutaneous allodynia develops in a 42-year-old male. Before the headache, he had various aura symptoms. During the…