Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Botulinum Toxin Type A as a Migraine Preventive Treatment
Botulinum toxin type A, known as BOTOX, is assessed for migraine prevention. Current treatments often fail due to low effectiveness or adverse effects. BOTOX injections help relieve pain from conditions like cervical…
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An association between migraine and cutaneous allodynia
Recent studies suggest that migraine leads to increased sensitivity in skin areas. This study aimed to explore whether this phenomenon occurs in humans. Researchers measured pain thresholds during migraine attacks…
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An international study to assess reliability of the Migraine Disability Assessment (MIDAS) score
The Migraine Disability Assessment (MIDAS) is a five-item questionnaire. It measures headache-related disability and improves doctor-patient communication about migraine effects. This study examined the reliability…
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The prevalence and characteristics of migraine in a population-based cohort
This study examined migraine prevalence and characteristics in the general population. Researchers analyzed data from 6,491 adults aged 20 to 65 years in the Netherlands. They found that 52.7% of selected…
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Burden of Migraine in the United States
Migraine is a common and disabling condition with significant economic impacts. This study estimated the burden of migraine in the United States. Researchers analyzed data from multiple sources, including published…
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Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
Familial hemiplegic migraine and episodic ataxia type-2 are linked to chromosome 19p13. Researchers studied a specific gene called CACNL1A4, which forms a brain-specific calcium channel. This gene consists of 47…
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Brain stem activation in spontaneous human migraine attacks
Researchers found that the brain stem plays a key role in migraines. They used positron emission tomography to study blood flow changes during migraine attacks. Increased blood flow occurred in the cingulate…
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Prevalence of headache and migraine in schoolchildren
A study in Aberdeen aimed to determine headache prevalence in schoolchildren. Researchers focused on migraine and its effects on school attendance. They surveyed 2165 children aged 5-15 years from 67 schools. The…
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Pathophysiology of the migraine aura
Migraine auras involve sensory disturbances linked to cerebral cortex disturbances. This suggests that cortical spreading depression (CSD) is a key mechanism. Changes in brain blood flow during migraine attacks…
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The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
Migraine is closely linked to the trigeminal innervation of cranial vessels. This study explored how the trigeminovascular system interacts with effective migraine medications. Researchers conducted experiments on…
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Prevalence of Migraine Headache in the United States
Migraine headache is a significant public health issue in the United States. This study examined migraine prevalence, frequency, and related disability across various demographics. In 1989, researchers sent…
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Migraine With Aura and Migraine Without Aura: An Epidemiological Study
In a study of 1,000 people, researchers examined migraine types and characteristics. They focused on migraine with aura (MA) and migraine without aura (MO). The study used interviews, physical exams, and diagnostic…
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Timing and topography of cerebral blood flow, aura, and headache during migraine attacks
Recent research has improved our understanding of migraine with aura. In this study, 63 patients were observed to identify patterns in cerebral blood flow. The first change noted was a decrease in blood flow in one…
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Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
Recent studies have explored the role of the trigeminovascular system in migraines. This system is connected to the cranial vessels and may influence migraine symptoms. Researchers stimulated the trigeminal ganglion…
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Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
A recent study investigated flunarizine's effectiveness in preventing childhood migraines. Seventy children participated in this 8-month double-blind, placebo-controlled, crossover trial. After four weeks without…
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Left-handedness: association with immune disease, migraine, and developmental learning disorder.
This study investigates the connection between left-handedness and certain health conditions. Researchers compared immune disease, migraine, and learning disorders in left-handed and right-handed individuals. They…
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Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
This study examined regional cerebral blood flow (rCBF) in migraine patients. Researchers measured rCBF in 254 brain areas using a special injection method. Six classic migraine cases were followed from normal states…
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Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial.
This study looked at how well antithrombotic treatment helps prevent migraines. It involved 1,000 adults aged 18 to 64 with patent foramen ovale (PFO). These participants had migraines for over a year and experienced…
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Quantitative Analysis of Pulmonary Right-to-Left Shunts and Patent Foramen Ovale via Agitated Saline Contrast Transesophageal Echocardiography: Associations With Migraine, Cryptogenic Stroke, and Transient Ischemic Attack.
This research examined the relationship between specific heart conditions and migraines. It focused on two types of right-to-left shunts in the heart: patent foramen ovale (PFO) and pulmonary right-to-left shunt…
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Migraine in the cradle of civilization: Evaluating ancient Mesopotamian texts through the lens of ICHD-3.
Migraine is a common neurological disorder that affects many people today. Researchers wanted to see if ancient texts described similar migraine symptoms. They studied 37 cuneiform medical texts from ancient…