Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.
Chronic pain conditions like migraine, neck pain, and low back pain often coexist. This review synthesizes shared mechanisms and treatments for these pain disorders. Researchers examined studies on central…
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U.S. Veterans Using Remote Electrical Neuromodulation for Migraine: A Prospective Real-World Evidence Study of Treatment Patterns, Medication Use, Effectiveness, and Safety (2020-2025).
Among U.S. veterans, migraines and headaches are very common. These disorders often co-occur with other health conditions. Thus, effective, well-tolerated, drug-free treatments are essential. Remote electrical…
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Perceived comfort with migraine treatments and control of migraine symptoms: Results from the Headache Assessment via Digital Platform in United States study.
This study aimed to identify factors influencing comfort with migraine treatments. It involved participants from the Headache Assessment via Digital Platform in the United States. The study found that 58% of…
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The integration of migraine and sleep disturbance in perimenopause: a narrative review.
This narrative review explores how migraine and sleep disturbances intersect during perimenopause. Hormone fluctuations worsen both migraine and sleep issues in women. Unfortunately, clinical guidelines for managing…
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Multimodal retinal imaging in migraine: Structural and vascular correlates of clinical characteristics.
This study evaluated retinal changes in migraine patients using optical coherence tomography. Researchers compared 68 eyes from migraine patients to 68 eyes from controls. The average age of participants was 35.8…
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Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism and Migraine Susceptibility and Phenotypes: A Clinical-Genetic Study in a United Arab Emirates (UAE) Cohort.
Migraine is a complex disorder with a significant genetic basis. The ACE insertion/deletion polymorphism may influence vascular regulation and neurovascular reactivity. This study aimed to assess its role in migraine…
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Caloric-vHIT Dissociation in Vestibular Migraine: An Observational, Retrospective Case Series Study.
Caloric-vHIT dissociation is often linked to Ménière's disease, but its role in vestibular migraine is unclear. This study aimed to analyze caloric-vHIT dissociation in seven patients with definite vestibular…
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Comparison of the Effectiveness of Greater Occipital Nerve (GON) Block and Sphenopalatine Ganglion (SPG) Block in the Treatment of Chronic Migraine.
Chronic migraine significantly affects quality of life and can be debilitating. This study compared the effectiveness of greater occipital nerve (GON) block and sphenopalatine ganglion (SPG) block. It involved 50…
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Evidence of Hypoxia Signaling and Endothelial Activation in Migraine: Relationships Between HIF-1α, VEGF-A, and Arginine Metabolism.
Migraine is a common neurovascular disorder that causes significant disability. This study explored the role of hypoxia signaling and endothelial dysfunction in chronic migraine. Researchers analyzed plasma samples…
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Peripheral Nerve Blocks in Adolescents with Medically Refractory Migraine: A Retrospective Observational Study.
This study evaluated the effectiveness and safety of peripheral nerve blocks in adolescents. Twenty-eight adolescents with refractory migraines were included in the assessment. The greater occipital nerve and lesser…
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Exercise & Migraine: Triggers, Prevention, and Management
Exercise has a complex relationship with headache disorders, especially migraines. Physical activity can trigger or worsen acute migraine attacks. However, exercise is also an effective preventive strategy for…
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Atypical Migraine? Consider Sjögren's: A Diagnostic Insight
Atypical presentations of Primary Sjögren's Syndrome can resemble migraine symptoms. This syndrome often starts with dry mouth and eyes but may also include migraines. A case study describes a 34-year-old woman…
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Cervical strengthening and stabilization exercises in migraine management: A systematic review.
Patients with migraines often receive referrals for physical therapy, especially with neck pain. Cervical strengthening and stabilization exercises are commonly suggested for these patients. However, the evidence…
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Allergic diseases in early childhood and their association with migraine: a large-scale retrospective study.
Migraine is a common neurological disorder affecting children. This study investigates the link between allergic diseases and migraine in early childhood. Researchers analyzed electronic medical records from a large…
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Association of transverse sinus stenosis and dominant venous sinus drainage pattern with chronic migraine: A matched case-control study.
Transverse sinus stenosis (TSS) may be important for chronic migraine (CM). This study included 94 CM patients and 94 matched controls. All participants underwent magnetic resonance venography to assess their venous…
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Osmophobia in Patients With Migraine: A Systematic Review and Meta-Analysis.
This study examined osmophobia in patients with migraine through systematic review. Researchers analyzed 58 studies involving 22,299 patients to determine osmophobia prevalence. The findings revealed that 48% of…
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Interictal burden in migraine: a systematic review of conceptual domains and measurement properties of instruments.
Migraine significantly affects individuals during acute attacks and headache-free periods. This research evaluates tools measuring the interictal burden of migraines. Patient-reported outcome measures (PROMs) assess…
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Wildfire-Sourced PM2.5 and Emergency Department Visits for Migraine and Other Primary Headache.
This study explores the link between wildfire smoke and migraine-related emergency department visits. Researchers focused on fine particulate matter from wildfires, known as PM2.5. The study analyzed data from…
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[Migraine aura: differential diagnostics between ophthalmology and neurology].
Migraine aura is a significant phase of migraine that deserves attention. About 25% to 35% of people with migraine experience temporary focal neurological symptoms. These symptoms usually develop gradually and spread…
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Association of Serum hs-CRP and TNF-α With Therapeutic Response to Erenumab for Migraine Prevention: A Registry for Migraine (REFORM) Study.
This study explored the role of inflammatory markers in predicting migraine treatment success. Researchers focused on two markers: high-sensitivity C-reactive protein and tumor necrosis factor-alpha. They studied…