Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Selective reduction of thalamic glutathione in migraine in the absence of detectable N-acetylaspartate alterations.
This study explores the role of oxidative stress in migraine. Researchers measured metabolites in the thalamus of 131 participants. These included 36 healthy controls, 46 migraine without aura, 17 migraine with aura…
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Real-world assessment of effectiveness and safety of candesartan in migraine prevention: Results of the French FHU InovPain registry.
Candesartan is recommended for migraine prevention, but real-world data is limited. This study analyzed adults starting candesartan in the French FHU InovPain registry. Patients were assessed at month 3, month 9, and…
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Differentiating Ménière Disease and Vestibular Migraine: A Prospective MRI Study of Endolymphatic Hydrops.
High-resolution MRI has improved the ability to detect endolymphatic hydrops. This advancement helps distinguish Ménière disease (MD) from vestibular migraine (VM). The study focused on patients experiencing vertigo…
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[Transgender health, migraine and headache-Underestimated associations, limited data situation].
Migraine and headache disorders are important in transgender patient care. Gender-affirming hormone therapies cause changes in physiological systems, affecting migraine symptoms. These changes align with the affirmed…
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Targeted liquid chromatography-tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy.
This study explored the role of specific amino acids in chronic migraine patients. Researchers evaluated plasma levels of arginine, histidine, and their derivatives. They aimed to identify potential biomarkers for…
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A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocyte-Platelet Score in Migraine.
Migraine is seen as a neuroinflammatory disorder with various inflammatory responses. This study examined leukocyte-derived indices like the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index…
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Impacts of cervical exercise and Mulligan manual therapy on headache frequency, intensity, and disability for people with episodic migraine - a randomized clinical trial.
This study aimed to compare Mulligan manual therapy (MMT) with sham MMT. Researchers involved 99 adults with episodic migraine, averaging 41.5 years old. Participants received either neck exercises alone, exercises…
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Acute migraine treatments in patients above age 65.
Migraine is common and disabling in older adults. However, research on treatment options for those over 65 years is limited. This age group often faces unique challenges, including special considerations for…
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Headache in mitochondrial diseases: From migraine to stroke-like episodes.
Headaches in primary mitochondrial diseases (PMDs) have unique features needing differentiation. These headaches affect about 55% to 71% of PMD patients. Individuals with mitochondrial encephalomyopathy, lactic…
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Safety and Effectiveness of Pain Medications for Migraine Management During Pregnancy and Lactation.
Managing migraines during pregnancy and lactation is quite challenging. There is limited safety data for migraine therapies during these periods. New treatments like CGRP blockers have little safety information…
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The Headache Needs Assessment (HANA) survey: psychometric properties of the Turkish version in migraine.
This study focused on adapting and validating the Turkish version of the Headache Needs Assessment survey. The survey contains seven items that assess migraine needs. Researchers evaluated structural validity using…
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Beyond air pollution: Green space, water minerals, and genetic predisposition in migraine onset.
This research studied the effects of green spaces, coastal distance, and water minerals on migraine onset. The study included 295,881 participants from the UK Biobank. These migraine-free individuals were followed…
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Gender inequities in the economic burden of anxiety disorders, depressive disorders, migraine, and rheumatoid arthritis in Mexico, 2005-2021.
Anxiety disorders, depressive disorders, migraine, and rheumatoid arthritis significantly impact health. These conditions lead to disability, recurrent care needs, and productivity losses. In Mexico, women are…
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Endolymphatic hydrops in patients with migraine: a correlative study.
This study looked at endolymphatic hydrops (EH) in migraine patients. EH is a hallmark of Menière's disease. Researchers examined MRI scans to find correlations with migraine biomarkers. They reviewed 144 inner ear…
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Superior sagittal sinus thrombosis presented as a migraine headache with normal D-dimer: a case report and literature review.
Superior sagittal sinus thrombosis (SSST) is a rare cerebral venous sinus thrombosis. It involves blood clot formation in the superior sagittal sinus. This leads to increased intracranial pressure. A remarkable case…
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Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis.
The glymphatic system is essential for clearing waste from the brain. Dysfunction in this system may contribute to migraine development. The glymphatic system operates similarly to the lymphatic system. It relies on…
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Dual-attention temporal graph neural network on resting-state fMRI dynamic functional connectivity identifies risk-related patterns of migraine chronification.
Migraine chronification is challenging to characterize on an individual basis. There are no robust imaging markers for the conversion from episodic migraine to chronic migraine. This study involved 195 participants…
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Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study.
Headache-associated symptoms like nausea and sensitivity help classify primary headache disorders. We developed a tool called Cluster Analysis of Migraine-Associated Symptoms, or CAMS. This tool captures the…
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EGR1-associated inflammatory and neurovascular signatures suggest a potential link between migraine and ischemic stroke.
Migraine increases the risk of ischemic stroke, but the mechanisms are unclear. This study analyzed RNA-seq data from ischemic stroke and a mouse migraine model. Researchers aimed to identify shared molecular…
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Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling.
Chronic migraine involves neuroinflammation in the trigeminal nucleus caudalis, or TNC. The herbal pair Paeoniae Radix Alba and Chuanxiong Rhizoma is commonly used for treatment. This study examined the effects of…