Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Non-Pharmacological Treatments of Migraine: Current Evidence and Clinical Practice.
Non-pharmacological treatments for migraine are increasingly popular for prevention. These methods may be preferred for sensitive populations like pregnant women and older adults. They can also complement traditional…
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Engineered Extracellular Vesicles As a New Delivery Platform for Migraine.
Migraine is a complex neurovascular disorder that's tough to treat effectively. The blood-brain barrier (BBB) complicates therapies targeting the trigeminovascular system and neuroinflammation. Current treatments…
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Hypothalamic subregional perfusion alterations in migraine: a 3D-PCASL study.
Migraine is a widespread neurological disorder involving the hypothalamus. This study explores blood flow changes in specific hypothalamic subregions. Researchers used three-dimensional pseudo-continuous arterial…
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Normative structural MRI deviation factors summarize patient-level neuroanatomical heterogeneity across episodic and chronic migraine.
In migraine research, structural MRI findings vary widely among different groups. This inconsistency may hide important patient-level differences in neuroanatomy. To explore this, we studied 249 adults with migraines…
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Hormonal, metabolic, and stress-related clinical differences between episodic and chronic migraine: insights for diagnostic and therapeutic approaches.
Migraine is a common neurological disorder with episodic (EM) and chronic (CM) forms. This study focused on hormonal and metabolic differences between these two groups. Researchers analyzed data from 500 patients…
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Genetic regulation of cell type-specific chromatin accessibility contributes to migraine etiology.
Migraine is a common and disabling neurological disorder affecting many individuals. Most causal regulatory variants remain unresolved, particularly concerning their target cell types. Disease-associated variants are…
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Metabolomic insights into migraine: mechanisms and biomarkers from in vivo and clinical studies.
Migraine is a complex neurological disorder with recurrent moderate to severe headaches. Symptoms often include nausea, photophobia, and phonophobia. Despite advances in neuroimaging, diagnosis still relies on…
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Comorbidity Between Restless Legs Syndrome and Migraine: Observations From a Tertiary Care Center in Northern India.
Migraine is a common headache disorder that causes significant disability. Recent studies show restless legs syndrome (RLS) often occurs alongside migraine. This is especially true for chronic migraines and those…
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Neurotrophins as neurobiological correlates of analytic visual information processing and migraine.
This study investigates if nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels reflect cognitive processing styles in healthy individuals and migraine patients. Researchers measured visual…
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The Impact of migraine on fertility and family planning in the Nationwide Swedish Health Care Registry.
Our study explored how migraine affects women's fertility and family planning decisions. We analyzed data from the Swedish National Registry, focusing on women born between 1973 and 1996. Our cohort included 49,318…
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Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine.
Self-assembled nanoaggregates (SANs) from herbal decoctions show promise as natural medicines. Wuzhuyu decoction (WZYD) is a traditional formula for treating migraines. This study focuses on how SANs in WZYD, called…
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PRT-064040: A nasal spray of novel, potent, and selective calcitonin gene-related peptide receptor antagonist for migraine.
Calcitonin gene-related peptide, or CGRP, is linked to migraine and other conditions. Researchers developed a new nasal spray called PRT-064040. This drug acts as a CGRP receptor antagonist. It aims to meet the…
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Electroacupuncture for Menstrual-Related Migraine: Protocol for a Multicenter Single-Blinded Randomized Controlled Trial.
Menstrual-related migraine (MRM) affects many females, causing severe symptoms and poor treatment responses. This condition significantly impacts their quality of life. Electroacupuncture may provide a…
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Comparative Efficacy and Acceptability of Noninvasive Brain Stimulation for Migraine: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
This network meta-analysis aimed to compare noninvasive brain stimulation techniques for migraine. Researchers searched various databases until October 13, 2025, for randomized controlled trials. The primary outcomes…
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Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.
Migraine is a common neurological disorder causing recurrent headaches. Female migraine patients often report less headache severity and frequency during late pregnancy. However, the reasons behind this phenomenon…
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Source-level α periodic power in visual and default mode networks predicts topiramate treatment response in migraine.
Migraine varies greatly among patients, making treatment responses unpredictable. This study focused on topiramate, a common preventive treatment. The dose-escalation strategy complicates early evaluation of its…
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IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.
Chronic migraine is a debilitating neurological condition involving neuroinflammation and central sensitization. This study focused on interleukin-1 receptor-associated kinase M (IRAK-M) in chronic migraine. IRAK-M…
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Migraine-advanced preventative treatments: the British Association for the Study of Headache Clinical Practice Recommendations and Consensus Guidance.
This document offers practical recommendations on advanced migraine treatments. It was developed by the British Association for the Study of Headache. The guidance is based on literature, expert opinions, and…
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Changes in Migraine-Related Outcomes and Functioning at 1 Year: Results of the Longitudinal OVERCOME (US) Study.
Migraine is a common neurological disorder that significantly affects quality of life. Understanding changes in migraine outcomes over time can improve clinical care. The OVERCOME study surveyed 11,634 adults with…
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Psychiatric and medical comorbidities in patients with migraine before and during the COVID-19 pandemic in Thailand: a retrospective comparative cohort study of two different clinical groups.
Migraine is often accompanied by psychiatric and medical comorbidities, worsening treatment results. This study looked at comorbidity prevalence in migraine patients before and during the COVID-19 pandemic. It…