Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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PRT-064040: A nasal spray of novel, potent, and selective calcitonin gene-related peptide receptor antagonist for migraine.
Calcitonin gene-related peptide, or CGRP, is linked to migraine and other conditions. Researchers developed a new nasal spray called PRT-064040. This drug acts as a CGRP receptor antagonist. It aims to meet the…
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Electroacupuncture for Menstrual-Related Migraine: Protocol for a Multicenter Single-Blinded Randomized Controlled Trial.
Menstrual-related migraine (MRM) affects many females, causing severe symptoms and poor treatment responses. This condition significantly impacts their quality of life. Electroacupuncture may provide a…
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Comparative Efficacy and Acceptability of Noninvasive Brain Stimulation for Migraine: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
This network meta-analysis aimed to compare noninvasive brain stimulation techniques for migraine. Researchers searched various databases until October 13, 2025, for randomized controlled trials. The primary outcomes…
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Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.
Migraine is a common neurological disorder causing recurrent headaches. Female migraine patients often report less headache severity and frequency during late pregnancy. However, the reasons behind this phenomenon…
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Source-level α periodic power in visual and default mode networks predicts topiramate treatment response in migraine.
Migraine varies greatly among patients, making treatment responses unpredictable. This study focused on topiramate, a common preventive treatment. The dose-escalation strategy complicates early evaluation of its…
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IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.
Chronic migraine is a debilitating neurological condition involving neuroinflammation and central sensitization. This study focused on interleukin-1 receptor-associated kinase M (IRAK-M) in chronic migraine. IRAK-M…
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Migraine-advanced preventative treatments: the British Association for the Study of Headache Clinical Practice Recommendations and Consensus Guidance.
This document offers practical recommendations on advanced migraine treatments. It was developed by the British Association for the Study of Headache. The guidance is based on literature, expert opinions, and…
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Changes in Migraine-Related Outcomes and Functioning at 1 Year: Results of the Longitudinal OVERCOME (US) Study.
Migraine is a common neurological disorder that significantly affects quality of life. Understanding changes in migraine outcomes over time can improve clinical care. The OVERCOME study surveyed 11,634 adults with…
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Psychiatric and medical comorbidities in patients with migraine before and during the COVID-19 pandemic in Thailand: a retrospective comparative cohort study of two different clinical groups.
Migraine is often accompanied by psychiatric and medical comorbidities, worsening treatment results. This study looked at comorbidity prevalence in migraine patients before and during the COVID-19 pandemic. It…
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Impact of Changing Migraine Outcome on Pharmacist Interventions in a Health-System Specialty Pharmacy.
Health-system specialty pharmacies play a crucial role in managing complex medical conditions. They focus on specialized medication therapy management, especially for migraines. This study aimed to evaluate whether…
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Persistent cognitive dysfunction in patients with migraine: a case series.
Cognitive symptoms like impaired concentration, slowed thinking, and forgetfulness are common in migraine patients. While these issues are strongest during attacks and postdrome phases, some individuals face…
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Migraine is associated with altered approach-avoidance decision processing: a case control study.
Individuals with migraine process trigger-related information differently than those without. This study examined decision-making in migraine patients using a virtual T-maze task. Participants faced both visual…
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A delayed endothelial-glial mechanism for CGRP-induced migraine.
CGRP plays a crucial role in migraine and trigeminovascular signaling. However, how CGRP causes delayed migraine-like pain after infusion is unclear. Although evidence supports CGRP’s role, the exact mechanisms…
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Factors Associated with Migraine Attack Duration in Adults: A Cross-Sectional Study.
Migraine is a prevalent neurological disorder with attacks lasting 4-72 hours. This study assessed 694 patients meeting ICHD-3 migraine criteria. Participants were divided into short, medium, and long attack duration…
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Periaqueductal gray matter echogenicity: An irreversible marker of chronic migraine?
This study investigated the periaqueductal gray matter (PAG) in migraine patients. Researchers aimed to see if PAG changes correlate with migraine classification shifts. They reanalyzed data from 115 participants…
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Chronic migraine management with onabotulinumtoxinA and anti-CGRP/R monoclonal antibodies in an Italian real-world setting: update on therapeutic appropriateness and an emerging role of pharmacy.
Migraine is a challenging neurovascular disorder that can progress to chronic forms. This progression may result in medication-overuse headache, leading to higher healthcare costs. The need for preventive treatments…
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Personalized machine learning prediction of next-day migraine persistence using digital headache diary data.
Migraine is a complex neurological disorder with considerable individual differences. Predicting if a migraine will continue into the next day is difficult. This study assessed personalized machine learning models…
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Thyroid dysfunction and migraine across racial and age groups: A multinational cohort study.
This study explores the link between thyroid dysfunction and migraine across different groups. Hypothyroidism affects over 200 million individuals globally, while hyperthyroidism impacts about 3% of adults. Migraine…
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Comparison of greater occipital and supraorbital nerve block with amitriptyline use in migraine treatment.
Migraine is a condition that often requires long-term preventive therapy. This study compares the effectiveness of greater occipital nerve (GON) and supraorbital nerve (SON) blockades against amitriptyline in…
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Regulatory T cell levels in migraine: A systematic review and meta-analysis.
This systematic review and meta-analysis examined regulatory T (Treg) cell levels in migraine patients. Researchers searched databases like PubMed, Embase, and Cochrane for relevant studies. They identified 1,162…