Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Pathophysiology of the migraine aura
Migraine auras involve sensory disturbances linked to cerebral cortex disturbances. This suggests that cortical spreading depression (CSD) is a key mechanism. Changes in brain blood flow during migraine attacks…
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The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
Migraine is closely linked to the trigeminal innervation of cranial vessels. This study explored how the trigeminovascular system interacts with effective migraine medications. Researchers conducted experiments on…
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Prevalence of Migraine Headache in the United States
Migraine headache is a significant public health issue in the United States. This study examined migraine prevalence, frequency, and related disability across various demographics. In 1989, researchers sent…
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Migraine With Aura and Migraine Without Aura: An Epidemiological Study
In a study of 1,000 people, researchers examined migraine types and characteristics. They focused on migraine with aura (MA) and migraine without aura (MO). The study used interviews, physical exams, and diagnostic…
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Timing and topography of cerebral blood flow, aura, and headache during migraine attacks
Recent research has improved our understanding of migraine with aura. In this study, 63 patients were observed to identify patterns in cerebral blood flow. The first change noted was a decrease in blood flow in one…
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Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
Recent studies have explored the role of the trigeminovascular system in migraines. This system is connected to the cranial vessels and may influence migraine symptoms. Researchers stimulated the trigeminal ganglion…
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Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
A recent study investigated flunarizine's effectiveness in preventing childhood migraines. Seventy children participated in this 8-month double-blind, placebo-controlled, crossover trial. After four weeks without…
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Left-handedness: association with immune disease, migraine, and developmental learning disorder.
This study investigates the connection between left-handedness and certain health conditions. Researchers compared immune disease, migraine, and learning disorders in left-handed and right-handed individuals. They…
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Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
This study examined regional cerebral blood flow (rCBF) in migraine patients. Researchers measured rCBF in 254 brain areas using a special injection method. Six classic migraine cases were followed from normal states…
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Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial.
This study looked at how well antithrombotic treatment helps prevent migraines. It involved 1,000 adults aged 18 to 64 with patent foramen ovale (PFO). These participants had migraines for over a year and experienced…
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Quantitative Analysis of Pulmonary Right-to-Left Shunts and Patent Foramen Ovale via Agitated Saline Contrast Transesophageal Echocardiography: Associations With Migraine, Cryptogenic Stroke, and Transient Ischemic Attack.
This research examined the relationship between specific heart conditions and migraines. It focused on two types of right-to-left shunts in the heart: patent foramen ovale (PFO) and pulmonary right-to-left shunt…
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Migraine in the cradle of civilization: Evaluating ancient Mesopotamian texts through the lens of ICHD-3.
Migraine is a common neurological disorder that affects many people today. Researchers wanted to see if ancient texts described similar migraine symptoms. They studied 37 cuneiform medical texts from ancient…
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Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.
Chronic pain conditions like migraine, neck pain, and low back pain often coexist. This review synthesizes shared mechanisms and treatments for these pain disorders. Researchers examined studies on central…
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U.S. Veterans Using Remote Electrical Neuromodulation for Migraine: A Prospective Real-World Evidence Study of Treatment Patterns, Medication Use, Effectiveness, and Safety (2020-2025).
Among U.S. veterans, migraines and headaches are very common. These disorders often co-occur with other health conditions. Thus, effective, well-tolerated, drug-free treatments are essential. Remote electrical…
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Perceived comfort with migraine treatments and control of migraine symptoms: Results from the Headache Assessment via Digital Platform in United States study.
This study aimed to identify factors influencing comfort with migraine treatments. It involved participants from the Headache Assessment via Digital Platform in the United States. The study found that 58% of…
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The integration of migraine and sleep disturbance in perimenopause: a narrative review.
This narrative review explores how migraine and sleep disturbances intersect during perimenopause. Hormone fluctuations worsen both migraine and sleep issues in women. Unfortunately, clinical guidelines for managing…
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Multimodal retinal imaging in migraine: Structural and vascular correlates of clinical characteristics.
This study evaluated retinal changes in migraine patients using optical coherence tomography. Researchers compared 68 eyes from migraine patients to 68 eyes from controls. The average age of participants was 35.8…
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Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism and Migraine Susceptibility and Phenotypes: A Clinical-Genetic Study in a United Arab Emirates (UAE) Cohort.
Migraine is a complex disorder with a significant genetic basis. The ACE insertion/deletion polymorphism may influence vascular regulation and neurovascular reactivity. This study aimed to assess its role in migraine…
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Caloric-vHIT Dissociation in Vestibular Migraine: An Observational, Retrospective Case Series Study.
Caloric-vHIT dissociation is often linked to Ménière's disease, but its role in vestibular migraine is unclear. This study aimed to analyze caloric-vHIT dissociation in seven patients with definite vestibular…
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Comparison of the Effectiveness of Greater Occipital Nerve (GON) Block and Sphenopalatine Ganglion (SPG) Block in the Treatment of Chronic Migraine.
Chronic migraine significantly affects quality of life and can be debilitating. This study compared the effectiveness of greater occipital nerve (GON) block and sphenopalatine ganglion (SPG) block. It involved 50…