Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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The Safety of OnabotulinumtoxinA (OnabotA) During Pregnancy and Breastfeeding: Implications for Chronic Migraines.
OnabotulinumtoxinA (OnabotA) is a treatment for chronic migraines. Migraines often affect women during pregnancy and breastfeeding. However, treatment options are limited for these women. This study looked at the…
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Migraine Symptom Progression During Pregnancy and Associations with Fetal Growth Patterns and Placental-Mediated Complications in Women with Pre-Existing Migraine: A Prospective Cohort Study.
This study looked at how migraines change during pregnancy and their effects. Researchers followed 400 pregnant women diagnosed with migraines before pregnancy. They assessed migraine symptoms, pregnancy…
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Pharmacological Modulation of the Kynurenine Pathway Using PF-04859989 Modulates PACAP Signaling in Migraine-Relevant Trigeminal Sensitization.
Migraine is a painful neurological condition that affects many people. Recent research focuses on a neuropeptide called PACAP, which contributes to migraine symptoms. The kynurenine pathway (KP) is also linked to…
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Effectiveness of Onabotulinumtoxin-A in Patients with Chronic Migraine and Previous CGRP-mAb Treatment Failure: A Multicentre 6-Month Real-World Experience.
Many patients with chronic migraine (CM) do not respond to standard treatments. Sometimes, they fail to benefit from medications targeting the CGRP pathway. This study looked at onabotulinumtoxin-A (BoNT-A) for these…
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Lomerizine Prophylaxis for Pediatric Migraine: Efficacy and Predictors of Treatment Response-A Retrospective Cohort Study.
Lomerizine is a medication used to prevent migraines, particularly in children. This study looked at 83 patients aged 18 and younger who received lomerizine. Researchers wanted to see how effective it was in reducing…
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Patient Preferences Toward CGRP-Targeting Preventive Migraine Treatments in Japan: Discrete Choice Experiment.
This study looked at Japanese patients' preferences for migraine treatments. It focused on new options called CGRP-targeting therapies, which include gepants and monoclonal antibodies. Researchers wanted to…
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Efficacy and Safety of Oral Zavegepant in Migraine Prevention: A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Study in Patients with Chronic Migraine.
This study explored the effectiveness and safety of oral zavegepant for chronic migraine prevention. It involved adults with a history of chronic migraines, experiencing many headache days each month. Participants…
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The role of non-coding RNAs in the pathogenesis of migraine: from molecular insights to potential biomarkers.
Non-coding RNAs (ncRNAs) play an important role in migraine development. These molecules help regulate gene expression and are linked to migraine symptoms. Researchers reviewed existing studies on microRNAs, long…
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Vestibular Migraine: A Systematic Literature Search and Narrative Review of Diagnostic Criteria, Pathophysiology, Differential Diagnosis, and Treatment Approaches.
This review highlights important findings about vestibular migraine. It summarizes diagnostic criteria and treatment options. Vestibular migraine is a type of migraine that causes dizziness and balance issues…
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Integrative genetic analysis identifies shared regulation of DNA methylation and gene expression in migraine risk.
Migraine is a common condition affecting about 14% of adults. Despite many studies identifying genetic risk factors, the exact biological mechanisms remain unclear. Environmental triggers like hormones, diet, and…
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CGRP receptor antagonism impairs microglial anti-inflammatory function: IL-4 supplementation as a compensatory strategy for migraine.
This study investigates the role of calcitonin gene-related peptide (CGRP) in migraine treatment. CGRP is a target for migraine therapies. Researchers found a surprising effect of CGRP receptor antagonists. These…
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A Three-Point, Low-Dose, Artery-Targeted Botulinum Toxin Treatment for Chronic Migraine: A Randomized, Double-Blind, Contralateral-Controlled Trial.
Chronic migraine is a common condition affecting many people. This study focused on using low-dose botulinum toxin type A (BoNT-A) to treat it. Researchers wanted to see if targeted injections along migraine-related…
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Elevated interictal plasma CGRP in Meniere's disease: A headache-independent candidate biomarker distinguishing Meniere's disease from vestibular migraine.
Researchers studied whether a blood protein called CGRP can help identify Ménière's disease (MD) from vestibular migraine (VM) and chronic migraine (CM). They collected blood samples from adults with MD, VM, CM, and…
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Efficacy and safety of Dingluo nasal drops for the acute treatment of migraine: a pilot randomized trial.
This study evaluated the effectiveness and safety of Dingluo nasal drops for treating migraines. Researchers conducted a trial with 91 participants who had 257 migraine attacks. Participants were randomly assigned to…
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TikTok as a source of information for migraine: a content quality analysis.
Migraine affects millions globally and is a leading neurological condition. Many people turn to TikTok for health information, including migraine-related content. This study examined the quality of TikTok videos…
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Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review.
Acupuncture may help treat migraines by protecting a key brain structure. This structure is called the neurovascular unit (NVU). The NVU plays an important role in migraine development. Researchers reviewed studies…
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Lifetime Probability of Developing Migraine: A Novel Epidemiological Perspective Based on Global Burden of Disease Data.
Migraine is a significant health issue, affecting over one billion people globally. This research focused on the lifetime probability of developing migraines. Using Global Burden of Disease 2021 data, researchers…
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Changes in P2X4 receptor expression following AbobotulinumtoxinA treatment in patients with chronic migraine: A case series study.
Chronic migraine (CM) is a serious condition that affects many people. AbobotulinumtoxinA (ABO-BoNT-A) is a common treatment for CM. However, how it works at a molecular level isn’t fully understood. This research…
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The Impact of Migraine on Cerebral Artery Dissection.
Migraine may increase the risk of cervicocerebral artery dissection, according to research. This study looked at patients with artery dissection and their migraine history. Researchers reviewed medical records to…
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[Triptan treatment in migraine: a dose-based model for persistence and acute medication use patterns using nationwide health insurance data].
This research examined how patients in Hungary use triptans for migraine treatment. Researchers analyzed data from 7840 patients who had never used triptans before. They looked at medication use over three-month…