Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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[Migraine aura: differential diagnostics between ophthalmology and neurology].
Migraine aura is a significant phase of migraine that deserves attention. About 25% to 35% of people with migraine experience temporary focal neurological symptoms. These symptoms usually develop gradually and spread…
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Association of Serum hs-CRP and TNF-α With Therapeutic Response to Erenumab for Migraine Prevention: A Registry for Migraine (REFORM) Study.
This study explored the role of inflammatory markers in predicting migraine treatment success. Researchers focused on two markers: high-sensitivity C-reactive protein and tumor necrosis factor-alpha. They studied…
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Tolerability, safety, and efficacy of atogepant versus topiramate in adults with migraine (TEMPLE): a randomised, head-to-head, phase 3b trial.
This research compares atogepant and topiramate for preventing migraines. Atogepant, a new oral treatment, is a CGRP receptor antagonist. Topiramate is an older, widely used preventive migraine treatment. However…
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Calcitonin Gene-Related Peptide Monoclonal Antibody Utilization and Treatment Gaps in People with Migraine in Japan: Results from the OVERCOME (Japan) 2nd Study.
Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) effectively prevent migraines. However, their use in Japan remains low. The OVERCOME (Japan) 2nd study analyzed CGRP mAb utilization patterns and…
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Migraine and the unpaid workload: Sex-specific patterns of domestic labor - insights from the SMILE project, a cohort study.
Migraine significantly impacts daily life, especially unpaid domestic labor. This study included 675 adults with migraine and 232 non-migraine controls. Participants completed surveys assessing demographics…
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A preliminary study on brain functional magnetic resonance imaging in migraine patients with visual aura using visual stimulation.
Migraine is common and often leads to recurrent attacks and poor treatment responses. This condition can greatly affect patients' quality of life. Aura symptoms complicate diagnosis and treatment, increasing…
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Migraine phenotypes defined by disability, pain topography and autonomic features: association with serum vitamin D status.
Migraine presents a wide range of symptoms and experiences among patients. This research explored how vitamin D levels relate to different migraine types. The study analyzed 95 patients, collecting data on various…
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Cochlear Functional Changes and CGRP Modulation in a Chronic Nitroglycerin Migraine-Like Rat Model.
Auditory and vestibular symptoms in migraine and inner ear conditions overlap significantly. However, the mechanisms linking migraine biology to inner ear dysfunction are still unclear. This study explored the role…
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When does empathy help? Patient-perceived physician empathy and migraine severity.
Migraine is a leading cause of disability worldwide. This research explored the link between patient-perceived physician empathy and migraine severity. Two studies involved 131 migraine patients, with various…
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Non-Pharmacological Treatments of Migraine: Current Evidence and Clinical Practice.
Non-pharmacological treatments for migraine are increasingly popular for prevention. These methods may be preferred for sensitive populations like pregnant women and older adults. They can also complement traditional…
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Engineered Extracellular Vesicles As a New Delivery Platform for Migraine.
Migraine is a complex neurovascular disorder that's tough to treat effectively. The blood-brain barrier (BBB) complicates therapies targeting the trigeminovascular system and neuroinflammation. Current treatments…
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Hypothalamic subregional perfusion alterations in migraine: a 3D-PCASL study.
Migraine is a widespread neurological disorder involving the hypothalamus. This study explores blood flow changes in specific hypothalamic subregions. Researchers used three-dimensional pseudo-continuous arterial…
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Normative structural MRI deviation factors summarize patient-level neuroanatomical heterogeneity across episodic and chronic migraine.
In migraine research, structural MRI findings vary widely among different groups. This inconsistency may hide important patient-level differences in neuroanatomy. To explore this, we studied 249 adults with migraines…
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Hormonal, metabolic, and stress-related clinical differences between episodic and chronic migraine: insights for diagnostic and therapeutic approaches.
Migraine is a common neurological disorder with episodic (EM) and chronic (CM) forms. This study focused on hormonal and metabolic differences between these two groups. Researchers analyzed data from 500 patients…
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Genetic regulation of cell type-specific chromatin accessibility contributes to migraine etiology.
Migraine is a common and disabling neurological disorder affecting many individuals. Most causal regulatory variants remain unresolved, particularly concerning their target cell types. Disease-associated variants are…
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Metabolomic insights into migraine: mechanisms and biomarkers from in vivo and clinical studies.
Migraine is a complex neurological disorder with recurrent moderate to severe headaches. Symptoms often include nausea, photophobia, and phonophobia. Despite advances in neuroimaging, diagnosis still relies on…
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Comorbidity Between Restless Legs Syndrome and Migraine: Observations From a Tertiary Care Center in Northern India.
Migraine is a common headache disorder that causes significant disability. Recent studies show restless legs syndrome (RLS) often occurs alongside migraine. This is especially true for chronic migraines and those…
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Neurotrophins as neurobiological correlates of analytic visual information processing and migraine.
This study investigates if nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels reflect cognitive processing styles in healthy individuals and migraine patients. Researchers measured visual…
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The Impact of migraine on fertility and family planning in the Nationwide Swedish Health Care Registry.
Our study explored how migraine affects women's fertility and family planning decisions. We analyzed data from the Swedish National Registry, focusing on women born between 1973 and 1996. Our cohort included 49,318…
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Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine.
Self-assembled nanoaggregates (SANs) from herbal decoctions show promise as natural medicines. Wuzhuyu decoction (WZYD) is a traditional formula for treating migraines. This study focuses on how SANs in WZYD, called…